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Israel Journal of Psychiatry and Related Sciences. Tachyphylaxis/tolerance to antidepressive medications: A review. Identification and treatment of antidepressant tachyphylaxis. Psychological counseling (psychotherapy) also may help.īecause there are so many reasons depression treatment can stop working, you may need to see a medical doctor who specializes in diagnosing and treating mental illness (psychiatrist) to figure out the best course of action. Your doctor may recommend that you change the dose of your current antidepressant, change to another antidepressant or add another antidepressant or other type of medication to your current treatment. In most cases, depression symptoms get better with adjustments to medication. All of these factors can play a role in depression. You're also likely to be taking more medications. In addition, the manner in which your body processes medications may be less efficient. As you get older, you may have changes in your brain and thinking (neurological changes) that affect your mood. In some people, depression gets worse with age. While an antidepressant is sometimes used to treat bipolar disorder, a mood-stabilizing or antipsychotic medication is generally needed along with an antidepressant to keep emotional highs and lows in check. Bipolar disorder, formerly called manic-depressive disorder, causes periodic mood swings. Some medications for unrelated conditions can interfere with the way your body breaks down and uses antidepressants, decreasing their effectiveness. Underlying health problems, such as hypothyroidism, can cause or worsen depression.

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The current dose of medication you're taking may not be enough to prevent your symptoms when depression gets worse. Called breakthrough depression, symptoms may be triggered by stress or appear with no apparent cause. It's common for depression symptoms to return or worsen at some point, despite treatment. There also can be other reasons an antidepressant is no longer working for you, such as:








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